Synovial tissue research: a state-of-the-art review.
Identifieur interne : 000316 ( Main/Exploration ); précédent : 000315; suivant : 000317Synovial tissue research: a state-of-the-art review.
Auteurs : Carl Orr [Irlande (pays)] ; Elsa Vieira-Sousa [Portugal] ; David L. Boyle [États-Unis] ; Maya H. Buch [Royaume-Uni] ; Christopher D. Buckley [Royaume-Uni] ; Juan D. Ca Ete [Espagne] ; Anca I. Catrina [Suède] ; Ernest H S. Choy [Royaume-Uni] ; Paul Emery [Royaume-Uni] ; Ursula Fearon [Irlande (pays)] ; Andrew Filer [Royaume-Uni] ; Danielle Gerlag [Pays-Bas] ; Frances Humby [Royaume-Uni] ; John D. Isaacs [Royaume-Uni] ; S Ren A. Just [Danemark] ; Bernard R. Lauwerys [Belgique] ; Benoit Le Goff [France] ; Antonio Manzo [Italie] ; Trudy Mcgarry [Irlande (pays)] ; Iain B. Mcinnes [Royaume-Uni] ; Aurélie Najm [France] ; Constantino Pitzalis [Royaume-Uni] ; Arthur Pratt [Royaume-Uni] ; Malcolm Smith [Australie] ; Paul P. Tak [Pays-Bas] ; Rogier Thurlings [Pays-Bas] ; João E. Fonseca [Portugal] ; Douglas J. Veale [Irlande (pays)]Source :
- Nature reviews. Rheumatology [ 1759-4804 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Membrane synoviale.
- cytologie : Membrane synoviale.
- diagnostic : Polyarthrite rhumatoïde.
- métabolisme : Marqueurs biologiques, Membrane synoviale, Polyarthrite rhumatoïde, Synovie.
- Humains, Recherche biomédicale.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Biomarkers.
- cytology : Synovial Membrane.
- diagnosis : Arthritis, Rheumatoid.
- metabolism : Arthritis, Rheumatoid, Synovial Fluid, Synovial Membrane.
- pathology : Synovial Membrane.
- Biomedical Research, Humans.
Abstract
The synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis. The study of synovial tissue has advanced considerably throughout the past few decades from arthroplasty and blind needle biopsy to the use of arthroscopic and ultrasonographic technologies that enable easier visualization and improve the reliability of synovial biopsies. Rapid progress has been made in using synovial tissue to study disease pathogenesis, to stratify patients, to discover biomarkers and novel targets, and to validate therapies, and this progress has been facilitated by increasingly diverse and sophisticated analytical and technological approaches. In this Review, we describe these approaches, and summarize how their use in synovial tissue research has improved our understanding of rheumatoid arthritis and identified candidate biomarkers that could be used in disease diagnosis and stratification, as well as in predicting disease course and treatment response.
DOI: 10.1038/nrrheum.2017.115
PubMed: 28701760
Affiliations:
- Australie, Belgique, Danemark, Espagne, France, Irlande (pays), Italie, Pays-Bas, Portugal, Royaume-Uni, Suède, États-Unis
- Angleterre, Catalogne, Grand Londres, Hollande-Septentrionale, Midlands de l'Ouest, Vienne (Autriche), Yorkshire-et-Humber, Écosse
- Amsterdam, Barcelone, Birmingham, Glasgow, Leeds, Londres, Vienne (Autriche)
- Université d'Amsterdam, Université de Birmingham, Université de Glasgow, Université de Leeds, Université de Londres
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Le document en format XML
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Buckley</name><affiliation wicri:level="4"><nlm:affiliation>Rheumatology Research Group, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Rheumatology Research Group, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT</wicri:regionArea><orgName type="university">Université de Birmingham</orgName><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Ca Ete, Juan D" sort="Ca Ete, Juan D" uniqKey="Ca Ete J" first="Juan D" last="Ca Ete">Juan D. Ca Ete</name><affiliation wicri:level="1"><nlm:affiliation>Arthritis Unit, Rheumatology Department, Hospital Clínic, IDIBAPS, Villarroel, 170, 08036 Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Arthritis Unit, Rheumatology Department, Hospital Clínic, IDIBAPS, Villarroel, 170, 08036 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Catrina, Anca I" sort="Catrina, Anca I" uniqKey="Catrina A" first="Anca I" last="Catrina">Anca I. Catrina</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology Unit, Department of Medicine (Solna), Karolinska Institute and Karolinska University Hospital, 171 76 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Rheumatology Unit, Department of Medicine (Solna), Karolinska Institute and Karolinska University Hospital, 171 76 Stockholm</wicri:regionArea><wicri:noRegion>171 76 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Choy, Ernest H S" sort="Choy, Ernest H S" uniqKey="Choy E" first="Ernest H S" last="Choy">Ernest H S. Choy</name><affiliation wicri:level="1"><nlm:affiliation>Cardiff University School of Medicine, Institute of Infection and Immunity, 1 st Floor, Tenovus Building, Heath Park, Cardiff CF14 4XN, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiff University School of Medicine, Institute of Infection and Immunity, 1 st Floor, Tenovus Building, Heath Park, Cardiff CF14 4XN</wicri:regionArea><wicri:noRegion>Cardiff CF14 4XN</wicri:noRegion></affiliation></author><author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name><affiliation wicri:level="4"><nlm:affiliation>Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author><author><name sortKey="Fearon, Ursula" sort="Fearon, Ursula" uniqKey="Fearon U" first="Ursula" last="Fearon">Ursula Fearon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Rheumatology, Trinity College Dublin, University of Dublin, College Green, Dublin 2, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Molecular Rheumatology, Trinity College Dublin, University of Dublin, College Green, Dublin 2</wicri:regionArea><wicri:noRegion>Dublin 2</wicri:noRegion></affiliation></author><author><name sortKey="Filer, Andrew" sort="Filer, Andrew" uniqKey="Filer A" first="Andrew" last="Filer">Andrew Filer</name><affiliation wicri:level="4"><nlm:affiliation>Rheumatology Research Group, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Rheumatology Research Group, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT</wicri:regionArea><orgName type="university">Université de Birmingham</orgName><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Gerlag, Danielle" sort="Gerlag, Danielle" uniqKey="Gerlag D" first="Danielle" last="Gerlag">Danielle Gerlag</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Immunology &Rheumatology, Amsterdam Rheumatology and Immunology Centre, Academic Medical Centre, University of Amsterdam, Room F4-105, POBox 22700, 1100 DE, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Immunology &Rheumatology, Amsterdam Rheumatology and Immunology Centre, Academic Medical Centre, University of Amsterdam, Room F4-105, POBox 22700, 1100 DE, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Humby, Frances" sort="Humby, Frances" uniqKey="Humby F" first="Frances" last="Humby">Frances Humby</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Experimental Medicine and Rheumatology, John Vane Science Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Experimental Medicine and Rheumatology, John Vane Science Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ</wicri:regionArea><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Isaacs, John D" sort="Isaacs, John D" uniqKey="Isaacs J" first="John D" last="Isaacs">John D. Isaacs</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH</wicri:regionArea><wicri:noRegion>NE2 4HH</wicri:noRegion></affiliation></author><author><name sortKey="Just, S Ren A" sort="Just, S Ren A" uniqKey="Just S" first="S Ren A" last="Just">S Ren A. Just</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Svendborg Hospital, Odense University Hospital, Valdemarsgade 53, 5700 Svendborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Medicine, Svendborg Hospital, Odense University Hospital, Valdemarsgade 53, 5700 Svendborg</wicri:regionArea><wicri:noRegion>5700 Svendborg</wicri:noRegion></affiliation></author><author><name sortKey="Lauwerys, Bernard R" sort="Lauwerys, Bernard R" uniqKey="Lauwerys B" first="Bernard R" last="Lauwerys">Bernard R. Lauwerys</name><affiliation wicri:level="3"><nlm:affiliation>Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Bruxelles, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Bruxelles</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Le Goff, Benoit" sort="Le Goff, Benoit" uniqKey="Le Goff B" first="Benoit" last="Le Goff">Benoit Le Goff</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology Unit, Nantes University Hospital, Hôtel-Dieu, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology Unit, Nantes University Hospital, Hôtel-Dieu, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1</wicri:regionArea><wicri:noRegion>44093 Nantes cedex 1</wicri:noRegion><wicri:noRegion>44093 Nantes cedex 1</wicri:noRegion></affiliation></author><author><name sortKey="Manzo, Antonio" sort="Manzo, Antonio" uniqKey="Manzo A" first="Antonio" last="Manzo">Antonio Manzo</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation/University of Pavia, P.le Golgi 19, 27100 Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation/University of Pavia, P.le Golgi 19, 27100 Pavia</wicri:regionArea><wicri:noRegion>27100 Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Mcgarry, Trudy" sort="Mcgarry, Trudy" uniqKey="Mcgarry T" first="Trudy" last="Mcgarry">Trudy Mcgarry</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Rheumatology, Trinity College Dublin, University of Dublin, College Green, Dublin 2, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Molecular Rheumatology, Trinity College Dublin, University of Dublin, College Green, Dublin 2</wicri:regionArea><wicri:noRegion>Dublin 2</wicri:noRegion></affiliation></author><author><name sortKey="Mcinnes, Iain B" sort="Mcinnes, Iain B" uniqKey="Mcinnes I" first="Iain B" last="Mcinnes">Iain B. Mcinnes</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences University of Glasgow, 120 University Avenue, Glasgow G12 8TA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences University of Glasgow, 120 University Avenue, Glasgow G12 8TA</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Najm, Aurelie" sort="Najm, Aurelie" uniqKey="Najm A" first="Aurélie" last="Najm">Aurélie Najm</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology Unit, Nantes University Hospital, Hôtel-Dieu, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology Unit, Nantes University Hospital, Hôtel-Dieu, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1</wicri:regionArea><wicri:noRegion>44093 Nantes cedex 1</wicri:noRegion><wicri:noRegion>44093 Nantes cedex 1</wicri:noRegion></affiliation></author><author><name sortKey="Pitzalis, Constantino" sort="Pitzalis, Constantino" uniqKey="Pitzalis C" first="Constantino" last="Pitzalis">Constantino Pitzalis</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Experimental Medicine and Rheumatology, John Vane Science Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Experimental Medicine and Rheumatology, John Vane Science Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ</wicri:regionArea><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pratt, Arthur" sort="Pratt, Arthur" uniqKey="Pratt A" first="Arthur" last="Pratt">Arthur Pratt</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH</wicri:regionArea><wicri:noRegion>NE2 4HH</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Malcolm" sort="Smith, Malcolm" uniqKey="Smith M" first="Malcolm" last="Smith">Malcolm Smith</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology, Flinders University, GPO Box 2100, Adelaide 5001, South Australia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Rheumatology, Flinders University, GPO Box 2100, Adelaide 5001, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Tak, Paul P" sort="Tak, Paul P" uniqKey="Tak P" first="Paul P" last="Tak">Paul P. Tak</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Immunology &Rheumatology, Amsterdam Rheumatology and Immunology Centre, Academic Medical Centre, University of Amsterdam, Room F4-105, POBox 22700, 1100 DE, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Immunology &Rheumatology, Amsterdam Rheumatology and Immunology Centre, Academic Medical Centre, University of Amsterdam, Room F4-105, POBox 22700, 1100 DE, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Thurlings, Rogier" sort="Thurlings, Rogier" uniqKey="Thurlings R" first="Rogier" last="Thurlings">Rogier Thurlings</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Life Sciences, RadboudUMC, Theodoor Craanenlaan 11, Nijmegen 6525 GA, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Institute for Molecular Life Sciences, RadboudUMC, Theodoor Craanenlaan 11, Nijmegen 6525 GA</wicri:regionArea><wicri:noRegion>Nijmegen 6525 GA</wicri:noRegion></affiliation></author><author><name sortKey="Fonseca, Joao E" sort="Fonseca, Joao E" uniqKey="Fonseca J" first="João E" last="Fonseca">João E. Fonseca</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-035, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-035, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Veale, Douglas J" sort="Veale, Douglas J" uniqKey="Veale D" first="Douglas J" last="Veale">Douglas J. Veale</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Arthritis and Rheumatic Disease, University College Dublin, Dublin Academic Medical Centre, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Centre for Arthritis and Rheumatic Disease, University College Dublin, Dublin Academic Medical Centre, St. Vincent's University Hospital, Elm Park, Dublin 4</wicri:regionArea><wicri:noRegion>Dublin 4</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28701760</idno><idno type="pmid">28701760</idno><idno type="doi">10.1038/nrrheum.2017.115</idno><idno type="wicri:Area/PubMed/Corpus">000813</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000813</idno><idno type="wicri:Area/PubMed/Curation">000810</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000810</idno><idno type="wicri:Area/PubMed/Checkpoint">000810</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000810</idno><idno type="wicri:Area/Ncbi/Merge">004B11</idno><idno type="wicri:Area/Ncbi/Curation">004B11</idno><idno type="wicri:Area/Ncbi/Checkpoint">004B11</idno><idno type="wicri:Area/Main/Merge">000311</idno><idno type="wicri:Area/Main/Curation">000316</idno><idno type="wicri:Area/Main/Exploration">000316</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Synovial tissue research: a state-of-the-art review.</title><author><name sortKey="Orr, Carl" sort="Orr, Carl" uniqKey="Orr C" first="Carl" last="Orr">Carl Orr</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Arthritis and Rheumatic Disease, University College Dublin, Dublin Academic Medical Centre, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Centre for Arthritis and Rheumatic Disease, University College Dublin, Dublin Academic Medical Centre, St. Vincent's University Hospital, Elm Park, Dublin 4</wicri:regionArea><wicri:noRegion>Dublin 4</wicri:noRegion></affiliation></author><author><name sortKey="Vieira Sousa, Elsa" sort="Vieira Sousa, Elsa" uniqKey="Vieira Sousa E" first="Elsa" last="Vieira-Sousa">Elsa Vieira-Sousa</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-035, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-035, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Boyle, David L" sort="Boyle, David L" uniqKey="Boyle D" first="David L" last="Boyle">David L. Boyle</name><affiliation wicri:level="1"><nlm:affiliation>University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093</wicri:regionArea><wicri:noRegion>California 92093</wicri:noRegion></affiliation></author><author><name sortKey="Buch, Maya H" sort="Buch, Maya H" uniqKey="Buch M" first="Maya H" last="Buch">Maya H. Buch</name><affiliation wicri:level="4"><nlm:affiliation>Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author><author><name sortKey="Buckley, Christopher D" sort="Buckley, Christopher D" uniqKey="Buckley C" first="Christopher D" last="Buckley">Christopher D. Buckley</name><affiliation wicri:level="4"><nlm:affiliation>Rheumatology Research Group, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Rheumatology Research Group, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT</wicri:regionArea><orgName type="university">Université de Birmingham</orgName><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Ca Ete, Juan D" sort="Ca Ete, Juan D" uniqKey="Ca Ete J" first="Juan D" last="Ca Ete">Juan D. Ca Ete</name><affiliation wicri:level="1"><nlm:affiliation>Arthritis Unit, Rheumatology Department, Hospital Clínic, IDIBAPS, Villarroel, 170, 08036 Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Arthritis Unit, Rheumatology Department, Hospital Clínic, IDIBAPS, Villarroel, 170, 08036 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Catrina, Anca I" sort="Catrina, Anca I" uniqKey="Catrina A" first="Anca I" last="Catrina">Anca I. Catrina</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology Unit, Department of Medicine (Solna), Karolinska Institute and Karolinska University Hospital, 171 76 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Rheumatology Unit, Department of Medicine (Solna), Karolinska Institute and Karolinska University Hospital, 171 76 Stockholm</wicri:regionArea><wicri:noRegion>171 76 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Choy, Ernest H S" sort="Choy, Ernest H S" uniqKey="Choy E" first="Ernest H S" last="Choy">Ernest H S. Choy</name><affiliation wicri:level="1"><nlm:affiliation>Cardiff University School of Medicine, Institute of Infection and Immunity, 1 st Floor, Tenovus Building, Heath Park, Cardiff CF14 4XN, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiff University School of Medicine, Institute of Infection and Immunity, 1 st Floor, Tenovus Building, Heath Park, Cardiff CF14 4XN</wicri:regionArea><wicri:noRegion>Cardiff CF14 4XN</wicri:noRegion></affiliation></author><author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name><affiliation wicri:level="4"><nlm:affiliation>Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author><author><name sortKey="Fearon, Ursula" sort="Fearon, Ursula" uniqKey="Fearon U" first="Ursula" last="Fearon">Ursula Fearon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Rheumatology, Trinity College Dublin, University of Dublin, College Green, Dublin 2, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Molecular Rheumatology, Trinity College Dublin, University of Dublin, College Green, Dublin 2</wicri:regionArea><wicri:noRegion>Dublin 2</wicri:noRegion></affiliation></author><author><name sortKey="Filer, Andrew" sort="Filer, Andrew" uniqKey="Filer A" first="Andrew" last="Filer">Andrew Filer</name><affiliation wicri:level="4"><nlm:affiliation>Rheumatology Research Group, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Rheumatology Research Group, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT</wicri:regionArea><orgName type="university">Université de Birmingham</orgName><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Gerlag, Danielle" sort="Gerlag, Danielle" uniqKey="Gerlag D" first="Danielle" last="Gerlag">Danielle Gerlag</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Immunology &Rheumatology, Amsterdam Rheumatology and Immunology Centre, Academic Medical Centre, University of Amsterdam, Room F4-105, POBox 22700, 1100 DE, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Immunology &Rheumatology, Amsterdam Rheumatology and Immunology Centre, Academic Medical Centre, University of Amsterdam, Room F4-105, POBox 22700, 1100 DE, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Humby, Frances" sort="Humby, Frances" uniqKey="Humby F" first="Frances" last="Humby">Frances Humby</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Experimental Medicine and Rheumatology, John Vane Science Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Experimental Medicine and Rheumatology, John Vane Science Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ</wicri:regionArea><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Isaacs, John D" sort="Isaacs, John D" uniqKey="Isaacs J" first="John D" last="Isaacs">John D. Isaacs</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH</wicri:regionArea><wicri:noRegion>NE2 4HH</wicri:noRegion></affiliation></author><author><name sortKey="Just, S Ren A" sort="Just, S Ren A" uniqKey="Just S" first="S Ren A" last="Just">S Ren A. Just</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Svendborg Hospital, Odense University Hospital, Valdemarsgade 53, 5700 Svendborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Medicine, Svendborg Hospital, Odense University Hospital, Valdemarsgade 53, 5700 Svendborg</wicri:regionArea><wicri:noRegion>5700 Svendborg</wicri:noRegion></affiliation></author><author><name sortKey="Lauwerys, Bernard R" sort="Lauwerys, Bernard R" uniqKey="Lauwerys B" first="Bernard R" last="Lauwerys">Bernard R. Lauwerys</name><affiliation wicri:level="3"><nlm:affiliation>Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Bruxelles, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Bruxelles</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Le Goff, Benoit" sort="Le Goff, Benoit" uniqKey="Le Goff B" first="Benoit" last="Le Goff">Benoit Le Goff</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology Unit, Nantes University Hospital, Hôtel-Dieu, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology Unit, Nantes University Hospital, Hôtel-Dieu, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1</wicri:regionArea><wicri:noRegion>44093 Nantes cedex 1</wicri:noRegion><wicri:noRegion>44093 Nantes cedex 1</wicri:noRegion></affiliation></author><author><name sortKey="Manzo, Antonio" sort="Manzo, Antonio" uniqKey="Manzo A" first="Antonio" last="Manzo">Antonio Manzo</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation/University of Pavia, P.le Golgi 19, 27100 Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation/University of Pavia, P.le Golgi 19, 27100 Pavia</wicri:regionArea><wicri:noRegion>27100 Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Mcgarry, Trudy" sort="Mcgarry, Trudy" uniqKey="Mcgarry T" first="Trudy" last="Mcgarry">Trudy Mcgarry</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Rheumatology, Trinity College Dublin, University of Dublin, College Green, Dublin 2, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Molecular Rheumatology, Trinity College Dublin, University of Dublin, College Green, Dublin 2</wicri:regionArea><wicri:noRegion>Dublin 2</wicri:noRegion></affiliation></author><author><name sortKey="Mcinnes, Iain B" sort="Mcinnes, Iain B" uniqKey="Mcinnes I" first="Iain B" last="Mcinnes">Iain B. Mcinnes</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences University of Glasgow, 120 University Avenue, Glasgow G12 8TA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences University of Glasgow, 120 University Avenue, Glasgow G12 8TA</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Najm, Aurelie" sort="Najm, Aurelie" uniqKey="Najm A" first="Aurélie" last="Najm">Aurélie Najm</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology Unit, Nantes University Hospital, Hôtel-Dieu, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology Unit, Nantes University Hospital, Hôtel-Dieu, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1</wicri:regionArea><wicri:noRegion>44093 Nantes cedex 1</wicri:noRegion><wicri:noRegion>44093 Nantes cedex 1</wicri:noRegion></affiliation></author><author><name sortKey="Pitzalis, Constantino" sort="Pitzalis, Constantino" uniqKey="Pitzalis C" first="Constantino" last="Pitzalis">Constantino Pitzalis</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Experimental Medicine and Rheumatology, John Vane Science Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Experimental Medicine and Rheumatology, John Vane Science Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ</wicri:regionArea><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pratt, Arthur" sort="Pratt, Arthur" uniqKey="Pratt A" first="Arthur" last="Pratt">Arthur Pratt</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH</wicri:regionArea><wicri:noRegion>NE2 4HH</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Malcolm" sort="Smith, Malcolm" uniqKey="Smith M" first="Malcolm" last="Smith">Malcolm Smith</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology, Flinders University, GPO Box 2100, Adelaide 5001, South Australia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Rheumatology, Flinders University, GPO Box 2100, Adelaide 5001, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Tak, Paul P" sort="Tak, Paul P" uniqKey="Tak P" first="Paul P" last="Tak">Paul P. Tak</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Immunology &Rheumatology, Amsterdam Rheumatology and Immunology Centre, Academic Medical Centre, University of Amsterdam, Room F4-105, POBox 22700, 1100 DE, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Immunology &Rheumatology, Amsterdam Rheumatology and Immunology Centre, Academic Medical Centre, University of Amsterdam, Room F4-105, POBox 22700, 1100 DE, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Thurlings, Rogier" sort="Thurlings, Rogier" uniqKey="Thurlings R" first="Rogier" last="Thurlings">Rogier Thurlings</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Molecular Life Sciences, RadboudUMC, Theodoor Craanenlaan 11, Nijmegen 6525 GA, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Institute for Molecular Life Sciences, RadboudUMC, Theodoor Craanenlaan 11, Nijmegen 6525 GA</wicri:regionArea><wicri:noRegion>Nijmegen 6525 GA</wicri:noRegion></affiliation></author><author><name sortKey="Fonseca, Joao E" sort="Fonseca, Joao E" uniqKey="Fonseca J" first="João E" last="Fonseca">João E. Fonseca</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-035, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-035, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Veale, Douglas J" sort="Veale, Douglas J" uniqKey="Veale D" first="Douglas J" last="Veale">Douglas J. Veale</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Arthritis and Rheumatic Disease, University College Dublin, Dublin Academic Medical Centre, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Centre for Arthritis and Rheumatic Disease, University College Dublin, Dublin Academic Medical Centre, St. Vincent's University Hospital, Elm Park, Dublin 4</wicri:regionArea><wicri:noRegion>Dublin 4</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature reviews. Rheumatology</title><idno type="eISSN">1759-4804</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arthritis, Rheumatoid (diagnosis)</term><term>Arthritis, Rheumatoid (metabolism)</term><term>Biomarkers (metabolism)</term><term>Biomedical Research</term><term>Humans</term><term>Synovial Fluid (metabolism)</term><term>Synovial Membrane (cytology)</term><term>Synovial Membrane (metabolism)</term><term>Synovial Membrane (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Marqueurs biologiques (métabolisme)</term><term>Membrane synoviale (anatomopathologie)</term><term>Membrane synoviale (cytologie)</term><term>Membrane synoviale (métabolisme)</term><term>Polyarthrite rhumatoïde (diagnostic)</term><term>Polyarthrite rhumatoïde (métabolisme)</term><term>Recherche biomédicale</term><term>Synovie (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Membrane synoviale</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Membrane synoviale</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Synovial Membrane</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Polyarthrite rhumatoïde</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Arthritis, Rheumatoid</term><term>Synovial Fluid</term><term>Synovial Membrane</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Marqueurs biologiques</term><term>Membrane synoviale</term><term>Polyarthrite rhumatoïde</term><term>Synovie</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Synovial Membrane</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biomedical Research</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Recherche biomédicale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis. The study of synovial tissue has advanced considerably throughout the past few decades from arthroplasty and blind needle biopsy to the use of arthroscopic and ultrasonographic technologies that enable easier visualization and improve the reliability of synovial biopsies. Rapid progress has been made in using synovial tissue to study disease pathogenesis, to stratify patients, to discover biomarkers and novel targets, and to validate therapies, and this progress has been facilitated by increasingly diverse and sophisticated analytical and technological approaches. In this Review, we describe these approaches, and summarize how their use in synovial tissue research has improved our understanding of rheumatoid arthritis and identified candidate biomarkers that could be used in disease diagnosis and stratification, as well as in predicting disease course and treatment response.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Irlande (pays)</li><li>Italie</li><li>Pays-Bas</li><li>Portugal</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Catalogne</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Midlands de l'Ouest</li><li>Vienne (Autriche)</li><li>Yorkshire-et-Humber</li><li>Écosse</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Birmingham</li><li>Glasgow</li><li>Leeds</li><li>Londres</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université d'Amsterdam</li><li>Université de Birmingham</li><li>Université de Glasgow</li><li>Université de Leeds</li><li>Université de Londres</li></orgName></list><tree><country name="Irlande (pays)"><noRegion><name sortKey="Orr, Carl" sort="Orr, Carl" uniqKey="Orr C" first="Carl" last="Orr">Carl Orr</name></noRegion><name sortKey="Fearon, Ursula" sort="Fearon, Ursula" uniqKey="Fearon U" first="Ursula" last="Fearon">Ursula Fearon</name><name sortKey="Mcgarry, Trudy" sort="Mcgarry, Trudy" uniqKey="Mcgarry T" first="Trudy" last="Mcgarry">Trudy Mcgarry</name><name sortKey="Veale, Douglas J" sort="Veale, Douglas J" uniqKey="Veale D" first="Douglas J" last="Veale">Douglas J. Veale</name></country><country name="Portugal"><noRegion><name sortKey="Vieira Sousa, Elsa" sort="Vieira Sousa, Elsa" uniqKey="Vieira Sousa E" first="Elsa" last="Vieira-Sousa">Elsa Vieira-Sousa</name></noRegion><name sortKey="Fonseca, Joao E" sort="Fonseca, Joao E" uniqKey="Fonseca J" first="João E" last="Fonseca">João E. Fonseca</name></country><country name="États-Unis"><noRegion><name sortKey="Boyle, David L" sort="Boyle, David L" uniqKey="Boyle D" first="David L" last="Boyle">David L. Boyle</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Buch, Maya H" sort="Buch, Maya H" uniqKey="Buch M" first="Maya H" last="Buch">Maya H. Buch</name></region><name sortKey="Buckley, Christopher D" sort="Buckley, Christopher D" uniqKey="Buckley C" first="Christopher D" last="Buckley">Christopher D. Buckley</name><name sortKey="Choy, Ernest H S" sort="Choy, Ernest H S" uniqKey="Choy E" first="Ernest H S" last="Choy">Ernest H S. Choy</name><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name><name sortKey="Filer, Andrew" sort="Filer, Andrew" uniqKey="Filer A" first="Andrew" last="Filer">Andrew Filer</name><name sortKey="Humby, Frances" sort="Humby, Frances" uniqKey="Humby F" first="Frances" last="Humby">Frances Humby</name><name sortKey="Isaacs, John D" sort="Isaacs, John D" uniqKey="Isaacs J" first="John D" last="Isaacs">John D. Isaacs</name><name sortKey="Mcinnes, Iain B" sort="Mcinnes, Iain B" uniqKey="Mcinnes I" first="Iain B" last="Mcinnes">Iain B. Mcinnes</name><name sortKey="Pitzalis, Constantino" sort="Pitzalis, Constantino" uniqKey="Pitzalis C" first="Constantino" last="Pitzalis">Constantino Pitzalis</name><name sortKey="Pratt, Arthur" sort="Pratt, Arthur" uniqKey="Pratt A" first="Arthur" last="Pratt">Arthur Pratt</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Ca Ete, Juan D" sort="Ca Ete, Juan D" uniqKey="Ca Ete J" first="Juan D" last="Ca Ete">Juan D. Ca Ete</name></region></country><country name="Suède"><noRegion><name sortKey="Catrina, Anca I" sort="Catrina, Anca I" uniqKey="Catrina A" first="Anca I" last="Catrina">Anca I. Catrina</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Gerlag, Danielle" sort="Gerlag, Danielle" uniqKey="Gerlag D" first="Danielle" last="Gerlag">Danielle Gerlag</name></region><name sortKey="Tak, Paul P" sort="Tak, Paul P" uniqKey="Tak P" first="Paul P" last="Tak">Paul P. Tak</name><name sortKey="Thurlings, Rogier" sort="Thurlings, Rogier" uniqKey="Thurlings R" first="Rogier" last="Thurlings">Rogier Thurlings</name></country><country name="Danemark"><noRegion><name sortKey="Just, S Ren A" sort="Just, S Ren A" uniqKey="Just S" first="S Ren A" last="Just">S Ren A. Just</name></noRegion></country><country name="Belgique"><region name="Vienne (Autriche)"><name sortKey="Lauwerys, Bernard R" sort="Lauwerys, Bernard R" uniqKey="Lauwerys B" first="Bernard R" last="Lauwerys">Bernard R. Lauwerys</name></region></country><country name="France"><noRegion><name sortKey="Le Goff, Benoit" sort="Le Goff, Benoit" uniqKey="Le Goff B" first="Benoit" last="Le Goff">Benoit Le Goff</name></noRegion><name sortKey="Najm, Aurelie" sort="Najm, Aurelie" uniqKey="Najm A" first="Aurélie" last="Najm">Aurélie Najm</name></country><country name="Italie"><noRegion><name sortKey="Manzo, Antonio" sort="Manzo, Antonio" uniqKey="Manzo A" first="Antonio" last="Manzo">Antonio Manzo</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Smith, Malcolm" sort="Smith, Malcolm" uniqKey="Smith M" first="Malcolm" last="Smith">Malcolm Smith</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Synovial tissue research: a state-of-the-art review.
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